Custom Peptides
Cayman Chemical JWH 250 5hydroxyIndl meta 10mg
Expected to be a metabolite of JWH 250 that would be detectable both in serum and in urine; intended for research and forensic applications
Cayman Chemical CID-2745687 10mg
A reversible, competitive antagonist of GPR35, blocking activation by the synthetic agonist pamoic acid with a Ki of 12.8 nM; less potently blocks activation of GPR35 by zaprinast (IC50 = 160 nM); shows ~57-fold selectivity for GPR35 over the related receptor GPR55 (IC50 = 9.08 µM)
Cayman Chemical Aranidipine 10mg
A Cav3.2 antagonist; inhibits inward currents in Xenopus oocytes expressing human Cav3.2 channels at 10 µM; decreases mean blood pressure and increases heart rate in SHRs at 10 mg/kg; It increases aortic and coronary blood flow and decreases blood pressure, but not heart rate, in normotensive dogs at 0.3 mg/kg; decreases blood pressure, as well as increases coronary blood flow velocity and heart contractile force, in dogs at 10 UG/kg; inhibits diet-induced increases in serum levels of total cholesterol, phospholipids, and triglycerides, as well as reduces aortic plaque area, in rabbits fed a high-cholesterol diet at 3 or 10 mg/kg
Cayman Chemical 1S 3R3AmInocyclopentnol 10mg
A synthetic intermediate useful for pharmaceutical synthesis.
Cayman Chemical 6-APDBhydrochlorIde 10mg
An analytical reference standard categorized as a benzofuran; substitutes for (S)-(+)-MBDB and MMAI in two-lever drug discrimination tests in rats; intended for research and forensic applications
Cayman Chemical P110trIfluoroacetate salt 10mg
A peptide inhibitor of DRP1; selectively inhibits DRP1 GTPase activity over OPA1, MFN1, and dynamin 1 at 1 µM; inhibits the MPP+-induced protein-protein interaction between DRP1 and FIS1, as well as stress-induced DRP1 translocation to the mitochondria in SH-SY5Y cells; inhibits MPP+-induced mitochondrial apoptosis and autophagy in SH-SY5Y cells and MPP+-induced mitochondrial fragmentation and cell death in a primary rat dopaminergic neuronal model of Parkinson’s disease
Cayman Chemical Taraxasterol 10mg
A pentacyclic triterpene with diverse biological activities; decreases LPS-induced increases in the secreted levels of nitrite, PGE2, TNF-α, IL-1β, and IL-6 from RAW 264.7 cells at 5 and 12.5 UG/ml; reduces the levels of HBsAg, HBeAg, and HBV DNA secreted from HBV-infected HepG2 2.2.15 cells in a concentration-dependent manner; prevents increases in liver damage, hepatocyte apoptosis, serum levels of ALT and AST, and hepatic levels of MDA, as well as decreases in hepatic levels of GSH, SOD, and Bax in a mouse model of concanavalin A-induced liver injury at 10 mg/kg per day
Cayman Chemical 25I-NBOHhydrochlorIde 10mg
A derivative of 2C-I that acts as a potent agonist for the human serotonin 5-HT2A receptor (Ki = 0.061 nM); intended for research and forensic applications
Cayman Chemical 1Oleoyl2hydroxysnglycero 10mg
A lysophospholipid containing oleic acid (18:1) at the sn-1 position
Cayman Chemical 1 3DIpentadecnoyl GlycRol 10mg
A diacylglycerol; has been used as an internal standard for the quantification of ceramides and diacylglycerols in rat soleus muscle by LC-MS/MS
Cayman Chemical 123 TrImyrIstoloyl GlycRo 10mg
A triacylglycerol; has been found in Idiazabal cheese
Cayman Chemical 20 R-GInsenosIde Rh2 10mg
A steroid glycoside with diverse biological activities; inhibits the replication of MHV-68 (IC50 = 2.77 μM) and the lytic replication of human gammaherpes virus in BC3 cells; reduces levels of NO, PGE2, ROS, and pro-MMP-9 in LPS-stimulated RAW 264.7 cells; reduces ROS production and MMP-9 and MMP-2 activity in HaCat human keratinocytes; induces tumor cell apoptosis and reduces tumor growth in an H22 hepatocellular carcinoma mouse xenograft model at 4 mg/kg
Cayman Chemical BrnbrutInIb 10mg
A covalent BTK inhibitor (IC50 = 0.1 nM); >5,000-fold selective for BTK over a panel of 240 kinases but does inhibit TEC, BMX, and TMX (IC50s = 0.9, 1.5, and 5.0 nM, respectively); inhibits BCR stimulation-induced calcium flux in Ramos B cells (IC50 = 7.2 nM), as well as BCR stimulation-induced proliferation of, and CD86 surface expression in, peripheral B cells (IC50s = 0.04 and 0.3 nM, respectively); inhibits Fcγ receptor stimulation-induced TNF-α production in human PBMCs (IC50 = 0.3 nM); completely protective against bone destruction in a mouse model of collagen-induced arthritis at 0.5 mg/kg; reduces proteinuria and glomerular IgG immune complex deposition and increases survival in an NZB/W lupus-prone mouse model
Cayman Chemical Cyclo RGDfK 10mg
An inhibitor of αvβ3 integrin (IC50 = 1.33 nM); taken up into tumors in vivo and in vitro and it has been polymerized or conjugated to various fluorophores, radiolabels, and peptide sequences for use in fluorescent and PET imaging to study tumor cell adhesion